Chapter-2 Literature review
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چکیده
Tabrizi et al., 1996 synthesizes polymeric prodrugs of the diclofenac by attaching Diclofenac to poychloromethylstyrene, polyvinyl chloroacetate and polyethylene glycol through the hydrolyzable ester bonds, and assessed in vitro for usefulness as diclofenac prodrugs. These polymers were obsereved potentially useful as polymeric prodrugs but polyvinyl chloroacetate was found an appropriate carrier for release of the drug in human conditions.
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